Genes involved in sister chromatid separation are needed for b-type cyclin proteolysis in budding yeast

@article{Irniger1995GenesII,
  title={Genes involved in sister chromatid separation are needed for b-type cyclin proteolysis in budding yeast},
  author={Stefan Irniger and Simonetta Piatti and Christine Michaelis and Kim Nasmyth},
  journal={Cell},
  year={1995},
  volume={81},
  pages={269-277}
}
B-type cyclin destruction is necessary for exit from mitosis and the initiation of a new cell cycle. Through the isolation of mutants, we have identified three essential yeast genes, CDC16, CDC23, and CSE1, which are required for proteolysis of the B-type cyclin CLB2 but not of other unstable proteins. cdc23-1 mutants are defective in both entering and exiting anaphase. Their failure to exit anaphase can be explained by defective cyclin proteolysis. CDC23 is required at the metaphase/anaphase… CONTINUE READING
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B - Type Cyclin Proteolysis in Yeast 277 the activation of G 1 cyclins in the next cycle

  • J. G. Ault, C. L. Rieder
  • 1994
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