Genes involved in immune response/inflammation, IGF1/insulin pathway and response to oxidative stress play a major role in the genetics of human longevity: the lesson of centenarians.

@article{Franceschi2005GenesII,
  title={Genes involved in immune response/inflammation, IGF1/insulin pathway and response to oxidative stress play a major role in the genetics of human longevity: the lesson of centenarians.},
  author={Claudio Franceschi and Fabiola Olivieri and Francesca Marchegiani and Maurizio Cardelli and Luca Cavallone and Miriam Capri and Stefano Salvioli and Silvana Valensin and Giovanna de Benedictis and Angelo Di Iorio and Calogero Caruso and Guiseppe Paolisso and Daniela Monti},
  journal={Mechanisms of ageing and development},
  year={2005},
  volume={126 2},
  pages={351-61}
}
In this paper, we review data of recent literature on the distribution in centenarians of candidate germ-line polymorphisms that likely affect the individual chance to reach the extreme limit of human life. On the basis of previous observations on the immunology, endocrinology and cellular biology of centenarians we focused on genes that regulate immune responses and inflammation (IL-6, IL-1 cluster, IL-10), genes involved in the insulin/IGF-I signalling pathway and genes that counteract… CONTINUE READING

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