Genes involved in complex adaptive processes tend to have highly conserved upstream regions in mammalian genomes

@article{Lee2005GenesII,
  title={Genes involved in complex adaptive processes tend to have highly conserved upstream regions in mammalian genomes},
  author={Soohyun Lee and Isaac S. Kohane and Simon Kasif},
  journal={BMC Genomics},
  year={2005},
  volume={6},
  pages={168 - 168}
}
BackgroundRecent advances in genome sequencing suggest a remarkable conservation in gene content of mammalian organisms. The similarity in gene repertoire present in different organisms has increased interest in studying regulatory mechanisms of gene expression aimed at elucidating the differences in phenotypes. In particular, a proximal promoter region contains a large number of regulatory elements that control the expression of its downstream gene. Although many studies have focused on… CONTINUE READING

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