Genes in the insulin and insulin-like growth factor pathway and odds of metachronous colorectal neoplasia

@article{Leroy2010GenesIT,
  title={Genes in the insulin and insulin-like growth factor pathway and odds of metachronous colorectal neoplasia},
  author={Elizabeth C Leroy and Jason H. Moore and Chengcheng Hu and Mar{\'i}a Elena Mart{\'i}nez and Peter M Lance and David Duggan and Patricia A. Thompson},
  journal={Human Genetics},
  year={2010},
  volume={129},
  pages={503-512}
}
Insulin and insulin-like growth factor (IGF) genes are implicated in colorectal carcinogenesis. Gene-by-gene interactions that influence the insulin/IGF pathways were hypothesized as modifiers of colorectal neoplasia risk. We built a classification tree to detect interactions in 18 IGF and insulin pathway-related genes and metachronous colorectal neoplasia among 1,439 subjects pooled from two chemoprevention trials. The probability of colorectal neoplasia was greatest (71.8%) among carriers of… CONTINUE READING

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References

Publications referenced by this paper.
Showing 1-10 of 48 references

Genetic determinants of circulating insulin-like growth factor (IGF)-I, IGF binding protein (BP)-1, and IGFBP-3 levels in a multiethnic population

I Cheng, K DeLellis Henderson, +4 authors L Le Marchand
J Clin Endocrinol Metab • 2007
View 6 Excerpts
Highly Influenced

Associations among IRS1, IRS2, IGF1, and IGFBP3 genetic polymorphisms and colorectal cancer.

Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology • 2004
View 7 Excerpts
Highly Influenced

IGF -I (CA) repeat polymorphisms and risk of cancer: a meta-analysis

Journal of Human Genetics • 2008
View 5 Excerpts
Highly Influenced

IGF1 is a modifier of disease risk in hereditary non-polyposis colorectal cancer.

International journal of cancer • 2008
View 4 Excerpts
Highly Influenced

Serum concentrations of insulin-like growth factor and insulin-like growth factor binding protein 3 and recurrent colorectal adenomas.

Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology • 2008
View 10 Excerpts
Highly Influenced

IGF1 gene polymorphism and risk for hereditary nonpolyposis colorectal cancer.

Journal of the National Cancer Institute • 2006
View 4 Excerpts
Highly Influenced

A new single nucleotide polymorphism in the insulin-like growth factor I regulatory region associates with colorectal cancer risk in singapore chinese.

Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology • 2005
View 4 Excerpts
Highly Influenced

Insulin resistance, apoptosis, and colorectal adenoma risk.

Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology • 2005
View 8 Excerpts
Highly Influenced

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