Genes for two autosomal recessive forms of chronic granulomatous disease assigned to 1q25 (NCF2) and 7q11.23 (NCF1).

@article{Francke1990GenesFT,
  title={Genes for two autosomal recessive forms of chronic granulomatous disease assigned to 1q25 (NCF2) and 7q11.23 (NCF1).},
  author={Uta Francke and Christine Hsieh and Brigitte Foellmer and Karen J. Lomax and Harry L Malech and Thomas L Leto},
  journal={American journal of human genetics},
  year={1990},
  volume={47 3},
  pages={
          483-92
        }
}
Chronic granulomatous disease (CGD) is a heterogeneous group of inherited disorders of impaired superoxide production in phagocytes. The most common X-linked recessive form involves the CYBB locus in band Xp21.1 that encodes the membrane-bound beta subunit of the cytochrome b558 complex. Two autosomal recessive forms of CGD result from defects in cytosolic components of the phagocyte NADPH oxidase system, p47phox (NCF1) and p67phox (NCF2). By using human cDNA probes we have mapped the genes for… CONTINUE READING

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