Genes for schizophrenia? Recent findings and their pathophysiological implications

  title={Genes for schizophrenia? Recent findings and their pathophysiological implications},
  author={Paul J. Harrison and M. Owen},
  journal={The Lancet},
  • Paul J. Harrison, M. Owen
  • Published 2003
  • Medicine
  • The Lancet
  • CONTEXT Schizophrenia is highly heritable, but the genes have remained elusive. Identifying the genes is essential if the pathogenesis and pathophysiology of schizophrenia is finally to be understood, and to give the prospect of more effective treatment. STARTING POINT H Stefansson and colleagues (Am J Hum Genet 2002; 71: 877-92) showed association of the neuregulin (NRG1) gene with schizophrenia. Other recent papers describe six additional susceptibility genes. Replications are already being… CONTINUE READING

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