Genes for schizophrenia? Recent findings and their pathophysiological implications

@article{Harrison2003GenesFS,
  title={Genes for schizophrenia? Recent findings and their pathophysiological implications},
  author={Paul J. Harrison and M. Owen},
  journal={The Lancet},
  year={2003},
  volume={361},
  pages={417-419}
}
  • Paul J. Harrison, M. Owen
  • Published 2003
  • Medicine
  • The Lancet
  • CONTEXT Schizophrenia is highly heritable, but the genes have remained elusive. Identifying the genes is essential if the pathogenesis and pathophysiology of schizophrenia is finally to be understood, and to give the prospect of more effective treatment. STARTING POINT H Stefansson and colleagues (Am J Hum Genet 2002; 71: 877-92) showed association of the neuregulin (NRG1) gene with schizophrenia. Other recent papers describe six additional susceptibility genes. Replications are already being… CONTINUE READING

    Topics from this paper.

    Schizophrenia: genes at last?
    • 317
    • PDF
    Molecular genetic studies of schizophrenia
    • 192
    • PDF
    Recent advances in the genetics of schizophrenia.
    • 201
    • PDF
    The neurodevelopmental hypothesis of schizophrenia, revisited.
    • 612
    • PDF
    Recent genetic findings in schizophrenia and their therapeutic relevance
    • 133
    • PDF
    Neuregulin 1 and Schizophrenia: Genetics, Gene Expression, and Neurobiology
    • 419
    • PDF

    References

    Publications referenced by this paper.
    SHOWING 1-10 OF 35 REFERENCES
    Neuregulin 1 and susceptibility to schizophrenia.
    • 1,551
    • PDF
    Schizophrenia as a disorder of neurodevelopment.
    • 718