Genes for schizophrenia? Recent findings and their pathophysiological implications

@article{Harrison2003GenesFS,
  title={Genes for schizophrenia? Recent findings and their pathophysiological implications},
  author={Paul J. Harrison and Michael John Owen},
  journal={The Lancet},
  year={2003},
  volume={361},
  pages={417-419}
}

Clinical impact of recently detected susceptibility genes for schizophrenia

There are now at least three very strong candidates: the gene for dysbindin (DINBP1), the genes for neuregulin-1 (NRG1), and a less well-understood gene locus, G72/G30, which are likely to influence manifestations of schizophrenia.

The genes for schizophrenia: Finally a breakthrough?

Though credible evidence is available for all of these genes, it is strongest for NRG1 and DTNBP1, and further studies, particularly exhaustive analyses of all polymorphisms at each locus, meta-analyses, and investigations of the likely function of risk alleles (variants) are desirable.

Schizophrenia: genes at last?

Recent genetic findings in schizophrenia and their therapeutic relevance

This review summarises recent schizophrenia genetic findings and some key issues they raise, particularly with regard to their implications for identifying and validating novel drug targets.

Recent advances in the genetics of schizophrenia.

The ability of positional genetics to implicate novel genes and pathways will open up new vistas for neurobiological research, and all the signs are that genetic research is poised to deliver crucial insights into the nature of schizophrenia.

In search of susceptibility genes for schizophrenia

An association of schizophrenia with the gene RGS4 (regulator of G protein signaling 4), a modulator of the function of multiple G-protein-linked neurotransmitter receptors, was identified andGene expression analyses of postmortem cerebral cortex indicate that the transcription of R GS4 is diminished within schizophrenia.

The molecular genetics of schizophrenia: new findings promise new insights

The ability of positional genetics to implicate novel genes and pathways will open up new vistas for neurobiological research, and all the signs are that it is now poised to deliver crucial insights into the nature of schizophrenia.

Genomic approaches to schizophrenia.

  • M. Owen
  • Medicine, Psychology
    Clinical therapeutics
  • 2005

Searching for inherited causes for schizophrenia: has progress been made?

This book currently outlines the conclusions drawn subsequent to the 5th meeting of investigators on “Search for the Causes of Schizophrenia”, and concludes that mathematical genetic modeling confirms the heritable component for schizophrenia.

Schizophrenia genes, gene expression, and neuropathology: on the matter of their convergence

This review critically summarizes the neuropathology and genetics of schizophrenia, the relationship between them, and speculates on their functional convergence via an influence upon synaptic plasticity and the development and stabilization of cortical microcircuitry.
...

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