Genes for immunoglobulin heavy chains and for α1-antitrypsin are localized to specific regions of chromosome 14q

@article{Cox1982GenesFI,
  title={Genes for immunoglobulin heavy chains and for α1-antitrypsin are localized to specific regions of chromosome 14q},
  author={Diane Wilson Cox and Vera D. Markovic and Ikuko E. Teshima},
  journal={Nature},
  year={1982},
  volume={297},
  pages={428-430}
}
Studies of somatic cell hybrids have assigned the gene cluster for human immunoglobulin heavy chains μ, γ and α to chromosome 14 (ref. 1). The locus for Gm (GM), a genetic marker on the γ heavy chain, has been shown to be linked to PI, the locus for α1-antitrypsin/α1-protease inhibitor (α1AT), a major protease inhibitor in human serum2,3. This assignment has now been confirmed by studies of somatic cell hybrids which have assigned α1AT also to chromosome 14 (refs 4,23). From studies of two… CONTINUE READING
37 Citations
0 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 37 extracted citations

Similar Papers

Loading similar papers…