Genes for enzymes regulating dehydroepiandrosterone sulfonation are associated with levels of dehydroepiandrosterone sulfate in polycystic ovary syndrome.

@article{Goodarzi2007GenesFE,
  title={Genes for enzymes regulating dehydroepiandrosterone sulfonation are associated with levels of dehydroepiandrosterone sulfate in polycystic ovary syndrome.},
  author={Mark O Goodarzi and Heath J. Antoine and Ricardo Azziz},
  journal={The Journal of clinical endocrinology and metabolism},
  year={2007},
  volume={92 7},
  pages={
          2659-64
        }
}
CONTEXT The adrenal androgen (AA) metabolite dehydroepiandrosterone sulfate (DHEAS) is often elevated in women with polycystic ovary syndrome (PCOS); AA excess in PCOS appears to be, in part, a heritable trait. Dehydroepiandrosterone (DHEA) sulfonation is controlled by the enzymes DHEA sulfotransferase (SULT2A1) and steroid sulfatase (STS). Polymorphisms in these genes have not been evaluated as modulators of DHEAS level in PCOS. OBJECTIVE The aim was to test the hypothesis that variants in… CONTINUE READING
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