Genes for embryo development are packaged in blocks of multivalent chromatin in zebrafish sperm.

@article{Wu2011GenesFE,
  title={Genes for embryo development are packaged in blocks of multivalent chromatin in zebrafish sperm.},
  author={Shan-Fu Wu and Haiying Zhang and Bradley R. Cairns},
  journal={Genome research},
  year={2011},
  volume={21 4},
  pages={578-89}
}
In mature human sperm, genes of importance for embryo development (i.e., transcription factors) lack DNA methylation and bear nucleosomes with distinctive histone modifications, suggesting the specialized packaging of these developmental genes in the germline. Here, we explored the tractable zebrafish model and found conceptual conservation as well as several new features. Biochemical and mass spectrometric approaches reveal the zebrafish sperm genome packaged in nucleosomes and histone… CONTINUE READING

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Histone H 3 methylation by Set 2 directs deacetylation of coding regions by Rpd 3 S to suppress spurious intragenic transcription

  • MJ Carrozza, B Li, +7 authors MP Washburn
  • Cell
  • 2005
Highly Influential
5 Excerpts

Long noncoding RNA as modular scaffold of histone modification complexes

  • ManorO TsaiMC, Y Wan, +5 authors HY Chang
  • Science
  • 2010

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