Genes for Tfb2, Tfb3, and Tfb4 subunits of yeast transcription/repair factor IIH. Homology to human cyclin-dependent kinase activating kinase and IIH subunits.

@article{Feaver1997GenesFT,
  title={Genes for Tfb2, Tfb3, and Tfb4 subunits of yeast transcription/repair factor IIH. Homology to human cyclin-dependent kinase activating kinase and IIH subunits.},
  author={William J. Feaver and N Lynn Henry and Zhen-Zhen Wang and Xue-song Wu and Jesper Qualmann Svejstrup and David A. Bushnell and Errol C. Friedberg and Roger D. Kornberg},
  journal={The Journal of biological chemistry},
  year={1997},
  volume={272 31},
  pages={19319-27}
}
Genes for the Tfb2, Tfb3, and Tfb4 subunits of yeast RNA polymerase transcription factor IIH (TFIIH) are described. All three genes are essential for cell viability, and antibodies against Tfb3 specifically inhibit transcription in vitro. A C-terminal deletion of Tfb2 caused a defect in nucleotide excision repair, as shown by UV sensitivity of the mutant strain and loss of nucleotide excision repair activity in cell extracts (restored by the addition of purified TFIIH). An interaction between… CONTINUE READING
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