Genes for Psychosis and Creativity

@article{Kri2009GenesFP,
  title={Genes for Psychosis and Creativity},
  author={Szabolcs K{\'e}ri},
  journal={Psychological Science},
  year={2009},
  volume={20},
  pages={1070 - 1073}
}
  • S. Kéri
  • Published 1 September 2009
  • Psychology, Biology
  • Psychological Science
Why are genetic polymorphisms related to severe mental disorders retained in the gene pool of a population? A possible answer is that these genetic variations may have a positive impact on psychological functions. Here, I show that a biologically relevant polymorphism of the promoter region of the neuregulin 1 gene (SNP8NRG243177/rs6994992) is associated with creativity in people with high intellectual and academic performance. Intriguingly, the highest creative achievements and creative… 

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References

SHOWING 1-10 OF 25 REFERENCES
A neuregulin 1 variant associated with abnormal cortical function and psychotic symptoms
TLDR
It is shown that a variant in the human NRG1 promoter region is associated with decreased activation of frontal and temporal lobe regions, increased development of psychotic symptoms and decreased premorbid IQ in subjects at high risk of schizophrenia.
A polymorphism of the neuregulin 1 gene (SNP8NRG243177/rs6994992) affects reactivity to expressed emotion in schizophrenia
  • S. Kéri, I. Kiss, Imola Seres, O. Kelemen
  • Psychology, Biology
    American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics
  • 2009
TLDR
The results raise the possibility that there is a significant gene by environment interaction regarding SNP8NRG243177/rs6994992 and psychosocial stress.
Neuregulin 1 and Schizophrenia: Genetics, Gene Expression, and Neurobiology
Neuregulin 1 Transcripts Are Differentially Expressed in Schizophrenia and Regulated by 5′ SNPs Associated With the Disease
TLDR
Bioinformatic promoter analyses indicate that both SNPs within the risk haplotype are associated with mRNA expression for the novel type IV isoform in patients and controls and lead to a gain/loss of putative binding sites for three transcription factors, serum response fac...
The effects of a neuregulin 1 variant on white matter density and integrity
TLDR
In the current study, unaffected subjects were genotyped at the NRG1 single nucleotide polymorphism (SNP) rs6994992 ( SNP8NRG243177) locus, previously associated with increased risk for psychosis, and the effect of genetic variation at this locus on white matter density and integrity was ascertained.
Decreased latent inhibition is associated with increased creative achievement in high-functioning individuals.
TLDR
Reductions in latent inhibition, the capacity to screen from conscious awareness stimuli previously experienced as irrelevant, have been generally associated with the tendency towards psychosis, but might also hypothetically contribute to original thinking, particularly in combination with high IQ.
The cognitive neuroscience of creativity
TLDR
A framework of creativity is outlined based on functional neuroanatomy that systematizes the interaction between knowledge and creative thinking, and how the nature of this relationship changes as a function of domain and age.
Molecular Cloning of a Brain-specific, Developmentally Regulated Neuregulin 1 (NRG1) Isoform and Identification of a Functional Promoter Variant Associated with Schizophrenia*♦
TLDR
The data suggest that type IV is a unique brain-specific NRG1 that is differentially expressed and processed during early development, is translated, and its expression regulated by a schizophrenia risk-associated functional promoter or single nucleotide polymorphism (SNP).
Unravelling Boléro: progressive aphasia, transmodal creativity and the right posterior neocortex.
TLDR
It is suggested that structural and functional enhancements in non-dominant posterior neocortex may give rise to specific forms of visual creativity that can be liberated by dominant inferior frontal cortex injury.
...
...