Genes for Psychosis and Creativity

  title={Genes for Psychosis and Creativity},
  author={Szabolcs K{\'e}ri},
  journal={Psychological Science},
  pages={1070 - 1073}
  • S. Kéri
  • Published 1 September 2009
  • Psychology, Biology
  • Psychological Science
Why are genetic polymorphisms related to severe mental disorders retained in the gene pool of a population? A possible answer is that these genetic variations may have a positive impact on psychological functions. Here, I show that a biologically relevant polymorphism of the promoter region of the neuregulin 1 gene (SNP8NRG243177/rs6994992) is associated with creativity in people with high intellectual and academic performance. Intriguingly, the highest creative achievements and creative… 

Tables from this paper

Does BDNF genotype influence creative output in bipolar I manic patients?
Creativity, psychosis and human evolution: The exemplar case of neuregulin 1 gene
Analyzing dN and dS are among the most direct ways to obtain evidence for positive selection on a protein-coding gene.
Creativity and Mental Illness: The evolutionary genetics of the creativity–psychosis connection
One possibility, which is explored in this chapter, is that schizophrenia remains in the human population (in part via the gene pool) because of shared genetic linkages to creativity (Andreasen, 2011) with acknowledgement of likely concurrent environmental influences.
Creativity and Psychopathology: A Shared Vulnerability Model
  • S. Carson
  • Psychology
    Canadian journal of psychiatry. Revue canadienne de psychiatrie
  • 2011
A model of shared vulnerability explains the relation between creativity and psychopathology and suggests that the biological determinants conferring risk for psychopathology interact with protective cognitive factors to enhance creative ideation.
The Association Between Schizophrenia Risk Variants and Creativity in Healthy Han Chinese Subjects
Limited evidence is provided for the associations between these schizophrenia risk variants and creativity in healthy Han Chinese subjects and future studies are warranted to better understand the potential genetic link between schizophrenia and creativity.
The Link between Creativity and Mental Health among the Students of the Universities in Tehran
According to Freud’s theory, the origin of creativity refers to the conflicts of unconscious mind. Psychologists, who came after Freud, reduced the effects of primary processes; moreover, explained
Schizophrenia-risk variant rs6994992 in the neuregulin-1 gene on brain developmental trajectories in typically developing children
To the knowledge, this work provides the first multimodal imaging evidence that genetic variation in NRG1 is associated with age-related changes on brain development during typical childhood and adolescence, and delineated the altered patterns of development in multiple brain regions in children with the T-risk allele(s).
Neural and genetic determinants of creativity
Association study between COMT 158 Met and creativity scores in bipolar disorder and healthy controls Estudo de associação entre COMT 158 Met e criatividade em sujeitos com transtorno bipolar e controles saudáveis
Background: Bipolar disorder (BD) patients have been reported to be associated higher creativity abilities, and recent data tend to support the hypothesis that dopaminergic system that could be


A neuregulin 1 variant associated with abnormal cortical function and psychotic symptoms
It is shown that a variant in the human NRG1 promoter region is associated with decreased activation of frontal and temporal lobe regions, increased development of psychotic symptoms and decreased premorbid IQ in subjects at high risk of schizophrenia.
A polymorphism of the neuregulin 1 gene (SNP8NRG243177/rs6994992) affects reactivity to expressed emotion in schizophrenia
  • S. Kéri, I. Kiss, Imola Seres, O. Kelemen
  • Psychology, Biology
    American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics
  • 2009
The results raise the possibility that there is a significant gene by environment interaction regarding SNP8NRG243177/rs6994992 and psychosocial stress.
Neuregulin 1 and Schizophrenia: Genetics, Gene Expression, and Neurobiology
Neuregulin 1 Transcripts Are Differentially Expressed in Schizophrenia and Regulated by 5′ SNPs Associated With the Disease
Bioinformatic promoter analyses indicate that both SNPs within the risk haplotype are associated with mRNA expression for the novel type IV isoform in patients and controls and lead to a gain/loss of putative binding sites for three transcription factors, serum response fac...
The effects of a neuregulin 1 variant on white matter density and integrity
In the current study, unaffected subjects were genotyped at the NRG1 single nucleotide polymorphism (SNP) rs6994992 ( SNP8NRG243177) locus, previously associated with increased risk for psychosis, and the effect of genetic variation at this locus on white matter density and integrity was ascertained.
Decreased latent inhibition is associated with increased creative achievement in high-functioning individuals.
Reductions in latent inhibition, the capacity to screen from conscious awareness stimuli previously experienced as irrelevant, have been generally associated with the tendency towards psychosis, but might also hypothetically contribute to original thinking, particularly in combination with high IQ.
The cognitive neuroscience of creativity
A framework of creativity is outlined based on functional neuroanatomy that systematizes the interaction between knowledge and creative thinking, and how the nature of this relationship changes as a function of domain and age.
Molecular Cloning of a Brain-specific, Developmentally Regulated Neuregulin 1 (NRG1) Isoform and Identification of a Functional Promoter Variant Associated with Schizophrenia*♦
The data suggest that type IV is a unique brain-specific NRG1 that is differentially expressed and processed during early development, is translated, and its expression regulated by a schizophrenia risk-associated functional promoter or single nucleotide polymorphism (SNP).
Unravelling Boléro: progressive aphasia, transmodal creativity and the right posterior neocortex.
It is suggested that structural and functional enhancements in non-dominant posterior neocortex may give rise to specific forms of visual creativity that can be liberated by dominant inferior frontal cortex injury.