Genes for Elite Power and Sprint Performance: ACTN3 Leads the Way

@article{Eynon2013GenesFE,
  title={Genes for Elite Power and Sprint Performance: ACTN3 Leads the Way},
  author={Nir Eynon and Erik D. Hanson and Alejandro Lucia and Peter J. Houweling and Fleur C. Garton and Kathryn N. North and David J. Bishop},
  journal={Sports Medicine},
  year={2013},
  volume={43},
  pages={803-817}
}
The ability of skeletal muscles to produce force at a high velocity, which is crucial for success in power and sprint performance, is strongly influenced by genetics and without the appropriate genetic make-up, an individual reduces his/her chances of becoming an exceptional power or sprinter athlete. Several genetic variants (i.e. polymorphisms) have been associated with elite power and sprint performance in the last few years and the current paradigm is that elite performance is a polygenic… 

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References

SHOWING 1-10 OF 139 REFERENCES
Genes and human elite athletic performance
TLDR
A review of the evidence that has accumulated over the last three decades for a strong genetic influence on human physical performance, with an emphasis on two sets of physical traits, viz. cardiorespiratory and skeletal muscle function, which are particularly important for performance in a variety of sports.
ACTN3 genotype is associated with human elite athletic performance.
TLDR
Associations between ACTN3 genotype and athletic performance suggest that the presence of alpha-actinin-3 has a beneficial effect on the function of skeletal muscle in generating forceful contractions at high velocity, and provides an evolutionary advantage because of increased sprint performance.
The combined impact of metabolic gene polymorphisms on elite endurance athlete status and related phenotypes
TLDR
Investigating individually and in combination the association of common metabolic gene polymorphisms with endurance athlete status, the proportion of slow-twitch muscle fibers and maximal oxygen consumption suggests that the likelihood of becoming an elite endurance athlete depends on the carriage of a high number of endurance-related alleles.
Genes and elite athletes: a roadmap for future research
TLDR
The present review aims to introduce novel methodological approaches in the field of sports genetics research, which can be applied in the near future to analyse the genotype profile associated with elite athletic status, using genotype–phenotype association studies using gene expression analysis, analysis of post‐transcriptional factors, and novel algorithm approaches.
The ACTN3 gene in elite Greek track and field athletes.
TLDR
The results suggest an overall strong association between the presence of the RR genotype and elite power performance in elite track and field athletes.
Association between ACE D allele and elite short distance swimming
TLDR
The results seem to support an association between the D allele and elite short distance swimming, which has been reported among elite endurance athletes and among healthy control subjects.
ACTN3 genotype is associated with increases in muscle strength in response to resistance training in women.
TLDR
Associations between ACTN3 genotype and muscle size and elbow flexor isometric and dynamic strength in a large group of men and women enrolled in a 12-wk standardized elbowflexor/extensor resistance training program of the nondominant arm were studied.
Genetic variation of the human ACE and ACTN3 genes and their association with functional muscle properties in Lithuanian elite athletes.
TLDR
L Lithuanian athletes who are carriers of the ACE I/I and I/D as well as ACTN3 X/X and R/X genotypes have the potential to achieve better results in power-requiring sports; therefore, the analyzed polymorphisms of these genes might be used as the criteria for the sport type selection.
ACTN3 and ACE genotypes in elite Jamaican and US sprinters.
TLDR
The finding of no excess in ACE DD or GG genotypes in elite sprint athletes relative to controls suggests that ACE genotype is not a determinant of elite sprint athlete status.
ACTN3 R577X polymorphism does not influence explosive leg muscle power in elite volleyball players
TLDR
It is suggested that the ACTN3 R577X polymorphism does not influence explosive leg muscle power in elite volleyball players and the likelihood of being an elite volleyball player using the dominant and recessive model.
...
1
2
3
4
5
...