Genes expressed during the differentiation of pancreatic AR42J cells into insulin-secreting cells.

@article{Mashima1999GenesED,
  title={Genes expressed during the differentiation of pancreatic AR42J cells into insulin-secreting cells.},
  author={Hirosato Mashima and Syu Yamada and Tatsuya Tajima and Masaharu Seno and Hisao Yamada and Jun Takeda and Itaru Kojima},
  journal={Diabetes},
  year={1999},
  volume={48 2},
  pages={
          304-9
        }
}
Pancreatic AR42J cells have the feature of pluripotency of the common precursor cells of the pancreas. Dexamethasone (Dx) converts them to exocrine cells, whereas activin A (Act) converts them into endocrine cells expressing pancreatic polypeptide. A combination of Act and betacellulin (BTC) converts them further into insulin-secreting cells. The present study identifies some of the genes involved in the process of differentiation that is induced by these factors, using the mRNA differential… CONTINUE READING