Genes encoding the acetaminophen and selenium binding proteins map to mouse chromosome 3

  title={Genes encoding the acetaminophen and selenium binding proteins map to mouse chromosome 3},
  author={Caryn Lynn Navarro and S. David Cohen and Edward A. Khairallah},
  journal={Mammalian Genome},
morphism was scored on the two backcross DNA panels from The Jackson Laboratory [2] to obtain the genetic map position by comparing the segregation patterns to all other loci previously typed in these panels. Results from 94 animals of the BSS backcross (C57BL/6JEi • SPRET/Ei) F 1 • SPRET/Ei showed that Mtap4 cosegregates with Pltr6 (polytrophic long terminal repeat [2]) on distal mouse Chr 9. Results from the reciprocal BSB backcross (C57BL/6J • Mus spretus) F 1 • C57BL/6J place the Mtap4… 


Maps from two interspecific backcross DNA panels available as a community genetic mapping resource
Large quantities of DNA from most tissues of each animal are prepared to create a community resource of interspecific backcross DNA for use by laboratories interested in mapping loci in the mouse.
Mapping of the novel G protein-coupled receptor Gprl8 to distal mouse chromosome 14
The two genes are tightly linked on mouse Chr 3, showing no recombinants with each other or the closest marker, D3Birl, and based on the high degree of homology between the two cDNAs, they most likely serve related cellular functions.
DNA sequencing of a mouse liver protein that binds selenium: implications for selenium's mechanism of action in cancer prevention.
The results suggest that SLP-56 is different from proteins whose synthesis and concentration are dependent upon selenium and require TGA to encode for selenocysteine, and appears to be similar to liver fatty acid binding protein (SLP-14) for which seenium is a ligand.
Different patterns of regulation of the genes encoding the closely related 56 kDa selenium- and acetaminophen-binding proteins in normal tissues and during carcinogenesis.
Isolation of genomic DNA recombinants from a Balb/c mouse cosmid genomic DNA library shows that SP56 and AP56 are encoded by two different genes, and uses reverse transcription/PCR with oligonucleotide primers to distinguish the AP56 and SP56 mRNAs to evaluate the postulated functions of the two proteins in mediating the anti-carcinogenic effects of selenium and detoxification mechanisms.
Gene–based sequence–tagged–sites (STSs) as the basis for a human gene map
Using the data set of 3,143 single pass sequences from human brain cDNA libraries, a strategy in which gene–based sequence–tagged–sites (STSs) are rapidly assigned to megabase–insert yeast artificial chromosomes and somatic cell hybrids to generate regional gene mapping data is developed.
Evidence for two selenium-binding proteins distinct from glutathione peroxidase in mouse liver.
The results indicate that the mouse liver contains at least two selenium-binding proteins distinct from GSH-Px, and the existence of the antibodies should permit experiments which help to examine the role of these proteins in the biological function of seenium in mammals.
Identification of the major covalent adduct formed in vitro and in vivo between acetaminophen and mouse liver proteins.
It is concluded that the reactive, electrophilic metabolite of acetaminophen, which most likely is N-acetyl-p-benzoquinoneimine, binds with a high degree of selectivity to cysteinyl thiol groups on protein, formally in a Michael-type addition reaction.
A metabolite of acetaminophen covalently binds to the 56 kDa selenium binding protein.