Genes encoding receptors for insulin and insulin-like growth factor I are expressed in Xenopus oocytes and embryos.

@article{Scavo1991GenesER,
  title={Genes encoding receptors for insulin and insulin-like growth factor I are expressed in Xenopus oocytes and embryos.},
  author={L M Scavo and Alan R. Shuldiner and Jose Salvador Serrano and Roger A Dashner and Judith Roth and Flora de Pablo},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1991},
  volume={88 14},
  pages={
          6214-8
        }
}
Insulin and insulin-like growth factor I (IGF-I) initiate their metabolic, growth, and differentiation effects through binding to the insulin receptor and the IGF-I receptor, two members of the tyrosine kinase family of receptors. To study the role of these peptides and receptors in early development, we used the polymerase chain reaction and embryo-derived RNA to generate partial cDNA sequences of the insulin receptor and IGF-I receptor from the amphibian Xenopus laevis. Three unique tyrosine… CONTINUE READING
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