Genes and addiction

@article{Nestler2000GenesAA,
  title={Genes and addiction},
  author={E. Nestler},
  journal={Nature Genetics},
  year={2000},
  volume={26},
  pages={277-281}
}
  • E. Nestler
  • Published 2000
  • Biology, Medicine
  • Nature Genetics
  • Drug addiction, like all psychiatric disorders, is defined solely in behavioural terms. For example, addiction can be considered a loss of control over drug-taking, or compulsive drug-seeking and -taking despite horrendous consequences. Abnormal behaviours are a consequence of aberrant brain function, which means that it is a tangible goal to identify the biological underpinnings of addiction. The genetic basis of addiction encompasses two broad areas of enquiry. One of these is the… CONTINUE READING
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    References

    SHOWING 1-10 OF 64 REFERENCES
    Molecular and cellular basis of addiction.
    • 1,313
    • PDF
    Role for GDNF in Biochemical and Behavioral Adaptations to Drugs of Abuse
    • 165
    Animal models of alcoholism: neurobiology of high alcohol-drinking behavior in rodents.
    • 560
    Drug-activation of brain reward pathways.
    • R. Wise
    • Psychology, Medicine
    • Drug and alcohol dependence
    • 1998
    • 662