Genes and Podocytes – New Insights into Mechanisms of Podocytopathy

@inproceedings{Bierzynska2014GenesAP,
  title={Genes and Podocytes – New Insights into Mechanisms of Podocytopathy},
  author={Agnieszka Bierzynska and Katrina Soderquest and Ania B. Koziell},
  booktitle={Front. Endocrinol.},
  year={2014}
}
After decades of primarily morphological study, positional cloning of the NPHS1 gene was the landmark event that established aberrant podocyte genetics as a pivotal cause of malfunction of the glomerular filter. This ended any uncertainty whether genetic mutation plays a significant role in hereditary nephrotic syndromes (NS) and confirmed podocytes as critical players in regulating glomerular protein filtration. Although subsequent sequencing of candidate genes chosen on the basis of podocyte… CONTINUE READING
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