Genes and Podocytes – New Insights into Mechanisms of Podocytopathy

  title={Genes and Podocytes – New Insights into Mechanisms of Podocytopathy},
  author={Agnieszka Bierzynska and Katrina Soderquest and Ania B. Koziell},
  booktitle={Front. Endocrinol.},
After decades of primarily morphological study, positional cloning of the NPHS1 gene was the landmark event that established aberrant podocyte genetics as a pivotal cause of malfunction of the glomerular filter. This ended any uncertainty whether genetic mutation plays a significant role in hereditary nephrotic syndromes (NS) and confirmed podocytes as critical players in regulating glomerular protein filtration. Although subsequent sequencing of candidate genes chosen on the basis of podocyte… CONTINUE READING
Related Discussions
This paper has been referenced on Twitter 1 time. VIEW TWEETS

From This Paper

Figures, tables, and topics from this paper.


Publications citing this paper.
Showing 1-10 of 17 extracted citations

Protein half-life determines expression of proteostatic networks in podocyte differentiation.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology • 2018
View 4 Excerpts
Highly Influenced

Genetic mutational testing of Chinese children with familial hematuria with biopsy-proven FSGS

Molecular medicine reports • 2018
View 13 Excerpts
Highly Influenced

Ethnic Differences in Childhood Nephrotic Syndrome

Front. Pediatr. • 2016
View 3 Excerpts
Highly Influenced

Recent advances of animal model of focal segmental glomerulosclerosis

Clinical and Experimental Nephrology • 2018
View 1 Excerpt


Publications referenced by this paper.
Showing 1-10 of 58 references

Podocyte biology and response to injury.

Journal of the American Society of Nephrology : JASN • 2002
View 11 Excerpts
Highly Influenced

A novel missense mutation of Wilms' Tumor 1 causes autosomal dominant FSGS.

Journal of the American Society of Nephrology : JASN • 2015
View 1 Excerpt

Similar Papers

Loading similar papers…