Genes and Mechanisms Related to RNA Interference Regulate Expression of the Small Temporal RNAs that Control C. elegans Developmental Timing

@article{Grishok2001GenesAM,
  title={Genes and Mechanisms Related to RNA Interference Regulate Expression of the Small Temporal RNAs that Control C. elegans Developmental Timing},
  author={Alla Grishok and Amy E Pasquinelli and Darryl Conte and Na Li and Susan Parrish and Ilho Ha and D. L. Baillie and Andrew Fire and Gary Ruvkun and Craig C. Mello},
  journal={Cell},
  year={2001},
  volume={106},
  pages={23-34}
}
RNAi is a gene-silencing phenomenon triggered by double-stranded (ds) RNA and involves the generation of 21 to 26 nt RNA segments that guide mRNA destruction. In Caenorhabditis elegans, lin-4 and let-7 encode small temporal RNAs (stRNAs) of 22 nt that regulate stage-specific development. Here we show that inactivation of genes related to RNAi pathway genes, a homolog of Drosophila Dicer (dcr-1), and two homologs of rde-1 (alg-1 and alg-2), cause heterochronic phenotypes similar to lin-4 and let… CONTINUE READING
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