Genes That Escape X-Inactivation in Humans Have High Intraspecific Variability in Expression, Are Associated with Mental Impairment but Are Not Slow Evolving

@inproceedings{Zhang2013GenesTE,
  title={Genes That Escape X-Inactivation in Humans Have High Intraspecific Variability in Expression, Are Associated with Mental Impairment but Are Not Slow Evolving},
  author={Yuchao Zhang and Atahualpa Castillo-Morales and Min Jiang and Yufei Zhu and Lan-Dian Hu and Araxi O Urrutia and Xiangyin Kong and Laurence D. Hurst},
  booktitle={Molecular biology and evolution},
  year={2013}
}
In female mammals most X-linked genes are subject to X-inactivation. However, in humans some X-linked genes escape silencing, these escapees being candidates for the phenotypic aberrations seen in polyX karyotypes. These escape genes have been reported to be under stronger purifying selection than other X-linked genes. Although it is known that escape from X-inactivation is much more common in humans than in mice, systematic assays of escape in humans have to date employed only interspecies… CONTINUE READING

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