Genes, proteases, cortical spreading depression and migraine: impact on pathophysiology and treatment.

@article{Moskowitz2007GenesPC,
  title={Genes, proteases, cortical spreading depression and migraine: impact on pathophysiology and treatment.},
  author={Michael A. Moskowitz},
  journal={Functional neurology},
  year={2007},
  volume={22 3},
  pages={133-6}
}
Migraine headaches have a complex pathophysiology; both vascular and neuronal mechanisms have been proposed. One possible scenario begins with a series of destabilising events within the brain that trigger cortical spreading depression (CSD). CSD can cause both migraine aura and trigeminal activation which, in turn, promotes neuropeptide release and triggers peripheral and central mechanisms that promote headache and autonomic activation. Susceptibility to CSD and to migraine is, in part… CONTINUE READING

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