Genes, environments, development and asthma: a reappraisal.

  title={Genes, environments, development and asthma: a reappraisal.},
  author={Fernando D. Martinez},
  journal={The European respiratory journal},
  volume={29 1},
Significant advances have been made in our understanding of the role of genetic variation in determining complex human phenotypes such as asthma. It is now well established that there is no single "gene for asthma", in the way that the cystic fibrosis transmembrane receptor is the "gene for cystic fibrosis". It is also clear that among all genetic variants eventually found to be associated with asthma, only a few will be replicated, and in the same direction, in the majority of well-performed… CONTINUE READING
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