Generic vancomycin products fail in vivo despite being pharmaceutical equivalents of the innovator.

  title={Generic vancomycin products fail in vivo despite being pharmaceutical equivalents of the innovator.},
  author={Omar Vesga and Mar{\'i}a Consuelo Castrill{\'o}n Agudelo and Beatriz E Salazar and Carlos A Rodriguez and Andr{\'e}s Felipe Zuluaga},
  journal={Antimicrobial agents and chemotherapy},
  volume={54 8},
Generic versions of intravenous antibiotics are not required to demonstrate therapeutic equivalence with the innovator because therapeutic equivalence is assumed from pharmaceutical equivalence. To test such assumptions, we studied three generic versions of vancomycin in simultaneous experiments with the innovator and determined the concentration and potency of the active pharmaceutical ingredient by microbiological assay, single-dose pharmacokinetics in infected mice, antibacterial effect by… CONTINUE READING
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