Generic substitution in the treatment of epilepsy: case evidence of breakthrough seizures.

  title={Generic substitution in the treatment of epilepsy: case evidence of breakthrough seizures.},
  author={Michael J Berg and Robert A. Gross and Kenneth J Tomaszewski and Wendy M Zingaro and Lisa S Haskins},
  volume={71 7},
OBJECTIVE There are concerns that generic and brand antiepileptic drugs (AEDs) may not be therapeutically equivalent. This study investigated how generic AED substitution may have negative consequences. METHODS Sixty-nine of 150 physicians who participated in a large survey on generic AED substitution completed a case review form regarding a patient who experienced a loss of seizure control due to a generic AED. Nineteen were excluded from analysis. RESULTS Fifty patients, well-controlled… CONTINUE READING

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Mandatory generic substitution of antiepileptic drugs raises concerns

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