Generic construction of single component particles that elicit humoural and cellular immune responses without the need for adjuvants.

@article{White2008GenericCO,
  title={Generic construction of single component particles that elicit humoural and cellular immune responses without the need for adjuvants.},
  author={Paul White and Frank Anastasopoulos and Jarrod E. Church and C-Y Kuo and Ben J Boyd and Pascal L C Hickey and Lam S Tu and P. N. Burns and Andrew M. Lew and William R Heath and Gayle M Davey and Colin W. Pouton},
  journal={Vaccine},
  year={2008},
  volume={26 52},
  pages={6824-31}
}
Insoluble, pure protein particles could be advantageous as single-entity vaccines or as carriers for small peptide epitopes. Dense gas anti-solvent precipitation was employed to produce pure protein particles which were found to be insoluble in water. As particulate and multimerized antigens are more immunogenic and hence more advantageous for vaccination, particles were produced via this method using ovalbumin as a model antigen. The particles produced had a mean diameter of approximately… CONTINUE READING

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