Generic binding sites, generic DNA-binding domains: where does specific promoter recognition come from?

@article{Georges2010GenericBS,
  title={Generic binding sites, generic DNA-binding domains: where does specific promoter recognition come from?},
  author={Adrien Georges and B{\'e}r{\'e}nice A Benayoun and Sandrine Caburet and Reiner A. Veitia},
  journal={FASEB journal : official publication of the Federation of American Societies for Experimental Biology},
  year={2010},
  volume={24 2},
  pages={
          346-56
        }
}
A transcription reaction relies on the specific recognition of cis-regulatory regions containing short DNA motifs. Such sequences are bound by transcription factors (TFs) involved in the recruitment, direct or not, of the transcriptional machinery. A eukaryotic genome can contain tens of genes encoding TFs that recognize very similar consensus DNA target sequences. In this review, we explore in a simple way how TFs coexpressed in the same cells and recognizing generic consensus sites with… CONTINUE READING

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