Generic and brand-name L-thyroxine are not bioequivalent for children with severe congenital hypothyroidism.

@article{Carswell2013GenericAB,
  title={Generic and brand-name L-thyroxine are not bioequivalent for children with severe congenital hypothyroidism.},
  author={Jeremi M. Carswell and Joshua H Gordon and Erica Y Popovsky and Andrea S Hale and Rosalind S. Brown},
  journal={The Journal of clinical endocrinology and metabolism},
  year={2013},
  volume={98 2},
  pages={610-7}
}
CONTEXT In the United States, generic substitution of levothyroxine (L-T(4)) by pharmacists is permitted if the formulations are deemed to be bioequivalent by the Federal Drug Administration, but there is widespread concern that the pharmacokinetic standard used is too insensitive. OBJECTIVE We aimed to evaluate the bioequivalence of a brand-name L-T(4) (Synthroid) and an AB-rated generic formulation (Sandoz, Princeton, NJ) in children with severe hypothyroidism. DESIGN This was a… CONTINUE READING
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