Generic Signals and Specific Outcomes Signaling through Ca2+, Calcineurin, and NF-AT

@article{Crabtree1999GenericSA,
  title={Generic Signals and Specific Outcomes Signaling through Ca2+, Calcineurin, and NF-AT},
  author={G. Crabtree},
  journal={Cell},
  year={1999},
  volume={96},
  pages={611-614}
}
  • G. Crabtree
  • Published 1999
  • Biology, Medicine
  • Cell
    • Why are drugs such as cyclosporin A and FK506 effective and specific immunosuppressants when their target, calcineurin is present in all tissues? A counterintuitive answer to this question arises from the unusual mechanism of action of these drugs (Liu et al. 1991xLiu, J, Farmer, J.D, Lane, W.S, Friedman, J, Weissman, I, and Schreiber, S.L. Cell. 1991; 66: 807–815Abstract | Full Text PDF | PubMed | Scopus (2779)See all ReferencesLiu et al. 1991). At therapeutic concentrations, cyclosporin and… CONTINUE READING
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    References

    SHOWING 1-10 OF 28 REFERENCES
    Calcineurin is a common target of cyclophilin-cyclosporin A and FKBP-FK506 complexes
    • 3,578
    Rapid shuttling of NF-AT in discrimination of Ca2+ signals and immunosuppression
    • 564
    Nuclear association of a T-cell transcription factor blocked by FK-506 and cyclosporin A
    • 982
    Nuclear localization of NF-ATc by a calcineurin-dependent, cyclosporin-sensitive intramolecular interaction.
    • 409
    • PDF
    Regulation of the Calmodulin-stimulated Protein Phosphatase, Calcineurin*
    • 854
    • PDF
    Transcription factors of the NFAT family: regulation and function.
    • 2,592
    • Highly Influential
    • PDF
    Cyclosporine induces cancer progression by a cell-autonomous mechanism
    • 1,017
    Activation and cellular localization of the cyclosporine A-sensitive transcription factor NF-AT in skeletal muscle cells.
    • 231
    • PDF
    Function of a heterologous muscarinic receptor in T cell antigen receptor signal transduction mutants.
    • 52
    A calcineurin-dependent transcriptional pathway controls skeletal muscle fiber type.
    • 979
    • PDF