Generic Signals and Specific Outcomes Signaling through Ca2+, Calcineurin, and NF-AT

  title={Generic Signals and Specific Outcomes Signaling through Ca2+, Calcineurin, and NF-AT},
  author={G. Crabtree},
  • G. Crabtree
  • Published 1999
  • Biology, Medicine
  • Cell
  • Why are drugs such as cyclosporin A and FK506 effective and specific immunosuppressants when their target, calcineurin is present in all tissues? A counterintuitive answer to this question arises from the unusual mechanism of action of these drugs (Liu et al. 1991xLiu, J, Farmer, J.D, Lane, W.S, Friedman, J, Weissman, I, and Schreiber, S.L. Cell. 1991; 66: 807–815Abstract | Full Text PDF | PubMed | Scopus (2779)See all ReferencesLiu et al. 1991). At therapeutic concentrations, cyclosporin and… CONTINUE READING
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