Calcineurin Directs the Reciprocal Regulation of Calcium Entry Pathways in Nonexcitable Cells*
- BiologyJournal of Biological Chemistry
Calcineurin is the key mediator of the reciprocal regulation of these co-existing channels, allowing each to play a unique and non-overlapping role in Ca2+ signaling.
Manipulating Immune Responses Review with Immunosuppressive Agents that Target NFAT
The thesis in this review is that since NFAT is a valimatory cytokines, the field of organ transplantation following its discovery in might be exploited to develop selective inhibitors of 1976 and compounds that interfere with NFAT regulation might have tic options.
Calcineurin and intracellular Ca2+-release channels: regulation or association?
- Biology, ChemistryBiochemical and biophysical research communications
Two distinct action mechanisms of immunophilin–ligand complexes for the blockade of T‐cell activation
- Biology, ChemistryEMBO reports
It is shown that FK506–FKBP complex suppresses the activation of JNK and p38 pathways at a level upstream of mitogen‐activated protein kinase (MAPK) kinase kinase ('MAPKK‐K) besides the calcineurin–NFAT pathway.
Direct Interaction and Reciprocal Regulation between ASK1 and Calcineurin-NFAT Control Cardiomyocyte Death and Growth
- Biology, ChemistryMolecular and Cellular Biology
Calcineurin and AsK1 cooperatively enhanced cardiomyocyte apoptosis, while expression of a dominant negative ASK1 blocked calcineur in-induced apoptosis and mouse embryonic fibroblasts deficient in ask1 were partially resistant to calcineURin- or ionomycin-induced suicides.
Synergism between the Calmodulin-binding and Autoinhibitory Domains on Calcineurin Is Essential for the Induction of Their Phosphatase Activity*
- Biology, ChemistryThe Journal of Biological Chemistry
It is shown here that the binding of CaM to CN may affect the conformation of CN at both the CaM-binding and the autoinhibitory domains and that this is critical for activation of CN to dephosphorylate NF-AT.
A salutary role for calcineurin in the heart.
- Biology, ChemistryJournal of molecular and cellular cardiology
Targeted inhibition of calcineurin attenuates cardiac hypertrophy in vivo
- Biology, MedicineProceedings of the National Academy of Sciences of the United States of America
Genetic evidence is provided implicating calcineurin as an important mediator of the cardiac hypertrophic response in vivo and adenoviral-mediated gene transfer was performed in the adult rat myocardium to evaluate the effectiveness of an acute intervention and any potential species dependency.
SHOWING 1-10 OF 28 REFERENCES
Calcineurin is a common target of cyclophilin-cyclosporin A and FKBP-FK506 complexes
- Biology, ChemistryCell
Rapid shuttling of NF-AT in discrimination of Ca2+ signals and immunosuppression
It is reported that sustained high concentrations of Ca2+, but not transient pulses, are required to maintain NF-AT transcription factors in the nucleus, where they participate in Ca2+-dependent induction of genes required for lymphocyte activation and proliferation.
Nuclear association of a T-cell transcription factor blocked by FK-506 and cyclosporin A
NF-AT is formed when a signal from the antigen receptor induces a pre-existing cytoplasmic subunit to translocate to the nucleus and combine with a newly synthesized nuclear subunit of NF-AT, forming a inhibitory complex between the drug and isomerase.
Nuclear localization of NF-ATc by a calcineurin-dependent, cyclosporin-sensitive intramolecular interaction.
- Biology, ChemistryGenes & development
It is shown that translocation requires two redundant nuclear localization sequences and that one sequence is in an intramolecular association with phosphorserines in a conserved motif located at the amino terminus of each NF-AT protein.
Regulation of the Calmodulin-stimulated Protein Phosphatase, Calcineurin*
- BiologyThe Journal of Biological Chemistry
The demonstration that FK506 and CsA, when bound to their respective binding proteins, are specific inhibitors of calcineurin provided the tools needed to reveal its many other roles in the transduction of Ca signals.
Transcription factors of the NFAT family: regulation and function.
- BiologyAnnual review of immunology
Recent data on the diversity of the NFAT family of transcription factors, the regulation of NFAT proteins within cells, and the cooperation ofNFAT proteins with other transcription factors to regulate the expression of inducible genes are discussed.
Cyclosporine induces cancer progression by a cell-autonomous mechanism
- Biology, MedicineNature
It is suggested that immunosuppressants like cyclosporine can promote cancer progression by a direct cellular effect that is independent of its effect on the host's immune cells, and that cyclospora-induced TGF-β production is involved in this.
Activation and cellular localization of the cyclosporine A-sensitive transcription factor NF-AT in skeletal muscle cells.
- BiologyMolecular biology of the cell
It is demonstrated that skeletal muscle cells express functionally active NF-AT proteins and that the nuclear translocation of individual NF- AT isoforms, which is essential for the ability to coordinate gene expression, is influenced markedly by the differentiation state of the muscle cell.
Function of a heterologous muscarinic receptor in T cell antigen receptor signal transduction mutants.
- BiologyThe Journal of biological chemistry
A calcineurin-dependent transcriptional pathway controls skeletal muscle fiber type.
- BiologyGenes & development
These results identify a molecular mechanism by which different patterns of motor nerve activity promote selective changes in gene expression to establish the specialized characteristics of slow and fast myofibers.