Generation of variability at VNTR loci in human DNA.

@article{Wolff1991GenerationOV,
  title={Generation of variability at VNTR loci in human DNA.},
  author={Roger K Wolff and Yasukazu Nakamura and S J Odelberg and Rita Shiang and R. White},
  journal={EXS},
  year={1991},
  volume={58},
  pages={20-38}
}
Our laboratory has constructed linkage maps of the human chromosomes to use as a tool towards the goal of cloning by position the genes responsible for genetic disorders. Construction of the map required the development of polymorphic marker systems in the form of Restriction Fragment Length Polymorphisms (RFLPs). Work by Yusuke Nakamura in the laboratory led to the identification of more than 200 highly informative Variable Number Tandem Repeat (VNTR) markers. The hypervariable nature of these… CONTINUE READING