Generation of urinary albumin fragments does not require proximal tubular uptake.

@article{Weyer2012GenerationOU,
  title={Generation of urinary albumin fragments does not require proximal tubular uptake.},
  author={Kathrin Weyer and Rikke Paludan Nielsen and Erik Ils{\o} Christensen and Henrik Birn},
  journal={Journal of the American Society of Nephrology : JASN},
  year={2012},
  volume={23 4},
  pages={
          591-6
        }
}
Urinary albumin excretion is an important diagnostic and prognostic marker of renal function. Both animal and human urine contain large amounts of albumin fragments, but whether these fragments originate from renal tubular degradation of filtered albumin is unknown. Here, we used mice with kidneys lacking megalin and cubilin, the coreceptors that mediate proximal tubular endocytosis of albumin, to determine whether proximal tubular degradation of albumin forms the detectable urinary albumin… CONTINUE READING
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Urine protein patterns

  • M Haubitz, S Wittke, +5 authors H Mischak
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