Generation of urinary albumin fragments does not require proximal tubular uptake.


Urinary albumin excretion is an important diagnostic and prognostic marker of renal function. Both animal and human urine contain large amounts of albumin fragments, but whether these fragments originate from renal tubular degradation of filtered albumin is unknown. Here, we used mice with kidneys lacking megalin and cubilin, the coreceptors that mediate… (More)
DOI: 10.1681/ASN.2011101034


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