Generation of tumor-specific T-lymphocytes by cross-priming with human dendritic cells ingesting apoptotic tumor cells.

@article{Hoffmann2000GenerationOT,
  title={Generation of tumor-specific T-lymphocytes by cross-priming with human dendritic cells ingesting apoptotic tumor cells.},
  author={Thomas K. Hoffmann and Norbert Meidenbauer and Grzegorz T Dworacki and Hiroshi Kanaya and Theresa L Whiteside},
  journal={Cancer research},
  year={2000},
  volume={60 13},
  pages={3542-9}
}
It has been suggested that dendritic cells (DCs) are capable of ingesting apoptotic tumor cells (ATCs) and presenting tumor-associated antigens to immune cells. We evaluated the potential of human DCs, which have ingested ATCs, to serve as a source of antigenic epitopes for presentation to T cells specific for PCI-13, a squamous cell carcinoma of the head and neck cell line. Immature DCs (DCimm) generated in the presence of interleukin 4 and granulocyte machrophage colony-stimulating factor… CONTINUE READING

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