Generation of tumor immunity by bone marrow-derived dendritic cells correlates with dendritic cell maturation stage.

@article{Labeur1999GenerationOT,
  title={Generation of tumor immunity by bone marrow-derived dendritic cells correlates with dendritic cell maturation stage.},
  author={M. S. Labeur and Berthold Roters and Birgit Pers and Annette Mehling and Thomas Anton Luger and Thomas V. Schwarz and Stephan Grabbe},
  journal={Journal of immunology},
  year={1999},
  volume={162 1},
  pages={
          168-75
        }
}
Bone marrow-derived dendritic cells (BmDC) are potent APC and can promote antitumor immunity in mice when pulsed with tumor Ag. This study aimed to define the culture conditions and maturation stages of BmDC that enable them to optimally function as APC in vivo. BmDC cultured under various conditions (granulocyte-macrophage CSF (GM-CSF) or GM-CSF plus IL-4 alone or in combination with Flt3 ligand, TNF-alpha, LPS, or CD40 ligand (CD40L)) were analyzed morphologically, phenotypically, and… CONTINUE READING

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