Generation of transgenic non-human primates with germline transmission

  title={Generation of transgenic non-human primates with germline transmission},
  author={E. Sasaki and H. Suemizu and A. Shimada and Kisaburo Hanazawa and Ryo Oiwa and M. Kamioka and I. Tomioka and Y. Sotomaru and Reiko Hirakawa and T. Eto and Seiji Shiozawa and T. Maeda and M. Ito and R. Ito and Chika Kito and Chie Yagihashi and K. Kawai and H. Miyoshi and Y. Tanioka and N. Tamaoki and S. Habu and H. Okano and T. Nomura},
  • E. Sasaki, H. Suemizu, +20 authors T. Nomura
  • Published 2009
  • Biology, Medicine
  • Nature
  • The common marmoset (Callithrix jacchus) is increasingly attractive for use as a non-human primate animal model in biomedical research. [...] Key Result Here we show that the injection of a self-inactivating lentiviral vector in sucrose solution into marmoset embryos results in transgenic common marmosets that expressed the transgene in several organs. Notably, we achieved germline transmission of the transgene, and the transgenic offspring developed normally. The successful creation of transgenic marmosets…Expand Abstract
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