• DOI:10.1038/nature08090
Corpus ID: 4404433

Generation of transgenic non-human primates with germline transmission

@article{Sasaki2009GenerationOT,
  title={Generation of transgenic non-human primates with germline transmission},
  author={E. Sasaki and H. Suemizu and A. Shimada and Kisaburo Hanazawa and Ryo Oiwa and M. Kamioka and I. Tomioka and Y. Sotomaru and Reiko Hirakawa and T. Eto and Seiji Shiozawa and T. Maeda and M. Ito and R. Ito and Chika Kito and Chie Yagihashi and K. Kawai and H. Miyoshi and Y. Tanioka and N. Tamaoki and S. Habu and H. Okano and T. Nomura},
  journal={Nature},
  year={2009},
  volume={459},
  pages={523-527}
}

E. Sasaki, H. Suemizu, +20 authors T. Nomura

Published 2009

Biology, Medicine

Nature

The common marmoset (Callithrix jacchus) is increasingly attractive for use as a non-human primate animal model in biomedical research. [...] Key Result Here we show that the injection of a self-inactivating lentiviral vector in sucrose solution into marmoset embryos results in transgenic common marmosets that expressed the transgene in several organs. Notably, we achieved germline transmission of the transgene, and the transgenic offspring developed normally. The successful creation of transgenic marmosets…Expand Abstract

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