Generation of transgenic mice producing a human transthyretin variant: a possible mouse model for familial amyloidotic polyneuropathy.

@article{Sasaki1986GenerationOT,
  title={Generation of transgenic mice producing a human transthyretin variant: a possible mouse model for familial amyloidotic polyneuropathy.},
  author={Hiroki Sasaki and Shigenobu T{\'o}ne and Masamitsu Nakazato and Katsuji Yoshioka and Hisayuki Matsuo and Yo Kato and Yoshiyuki Sakaki},
  journal={Biochemical and biophysical research communications},
  year={1986},
  volume={139 2},
  pages={794-9}
}
Type I familial amyloidotic polyneuropathy (FAP) results from the systemic deposition of a plasma transthyretin (TTR) variant with a Val----Met change at position 30. In an attempt to establish a model of this disease, we generated transgenic mice producing the variant TTR. A DNA fragment containing the mouse metallothionein-I promoter fused to the structural gene coding for the human TTR variant was microinjected into fertilized mouse eggs. Among 72 mice that developed from these eggs, ten… CONTINUE READING

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