Generation of the primary antibody repertoire in rabbits: expression of a diverse set of Igk-V genes may compensate for limited combinatorial diversity at the heavy chain locus

@article{Sehgal1999GenerationOT,
  title={Generation of the primary antibody repertoire in rabbits: expression of a diverse set of Igk-V genes may compensate for limited combinatorial diversity at the heavy chain locus},
  author={Devinder Sehgal and George Johnson and Tai Te Wu and Rose G. Mage},
  journal={Immunogenetics},
  year={1999},
  volume={50},
  pages={31-42}
}
 In mouse and human, generation of combinatorial diversity through use of different heavy and light chain variable region genes in immunoglobulin rearrangements can be a major contributor to the primary antibody repertoire. In rabbits, the contribution of the combinatorial mechanism to heavy chain diversity is minimal, as only a few Igh-V genes are rearranged and expressed. To investigate the contribution of combinatorial diversity toward generation of the rabbit Vκ repertoire, we constructed… CONTINUE READING
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