Generation of the human metabolite piceatannol from the anticancer-preventive agent resveratrol by bacterial cytochrome P450 BM3.

@article{Kim2009GenerationOT,
  title={Generation of the human metabolite piceatannol from the anticancer-preventive agent resveratrol by bacterial cytochrome P450 BM3.},
  author={Dong-Hyun Kim and Taeho Ahn and Heung-Chae Jung and J Pan and Chul-Ho Yun},
  journal={Drug metabolism and disposition: the biological fate of chemicals},
  year={2009},
  volume={37 5},
  pages={932-6}
}
In recent studies, the wild-type and mutant forms of cytochrome P450 (P450) BM3 (CYP102A1) from Bacillus megaterium were found to metabolize various drugs through reactions similar to those catalyzed by human P450 enzymes. Therefore, it was suggested that CYP102A1 can be used to produce large quantities of the metabolites of human P450-catalyzed reactions… CONTINUE READING