Generation of the AML1-EVI-1 fusion gene in the t(3;21)(q26;q22) causes blastic crisis in chronic myelocytic leukemia.

@article{Mitani1994GenerationOT,
  title={Generation of the AML1-EVI-1 fusion gene in the t(3;21)(q26;q22) causes blastic crisis in chronic myelocytic leukemia.},
  author={Kinuko Mitani and Seishi Ogawa and Toshihiro Tanaka and Hiroyuki Miyoshi and Mineo Kurokawa and Hiroyuki Mano and Yoshio Yazaki and M. Ohki and Hisamaru Hirai},
  journal={The EMBO journal},
  year={1994},
  volume={13 3},
  pages={504-10}
}
The t(3;21)(q26;q22) translocation, which is one of the consistent chromosomal abnormalities found in blastic crisis of chronic myelocytic leukemia (CML), is thought to play an important role in the leukemic progression of CML to an acute blastic crisis phase. The AML1 gene, which is located at the translocation breakpoint of the t(8;21)(q22;q22) translocation found in acute myelocytic leukemia, was also rearranged by the t(3;21)(q26;q22) translocation. Screening of a cDNA library of the t(3;21… CONTINUE READING

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