Generation of thalamic neurons from mouse embryonic stem cells.

@article{Shiraishi2017GenerationOT,
  title={Generation of thalamic neurons from mouse embryonic stem cells.},
  author={Atsushi Shiraishi and Keiko Muguruma and Yoshiki Sasai},
  journal={Development},
  year={2017},
  volume={144 7},
  pages={1211-1220}
}
The thalamus is a diencephalic structure that plays crucial roles in relaying and modulating sensory and motor information to the neocortex. The thalamus develops in the dorsal part of the neural tube at the level of the caudal forebrain. However, the molecular mechanisms that are essential for thalamic differentiation are still unknown. Here, we have succeeded in generating thalamic neurons from mouse embryonic stem cells (mESCs) by modifying the default method that induces the most-anterior… CONTINUE READING