Generation of suppressive blood cells for control of allograft rejection.

@article{Kleist2015GenerationOS,
  title={Generation of suppressive blood cells for control of allograft rejection.},
  author={Christian Kleist and Flavius Sandra-Petrescu and Lucian Petru Jiga and Laura Dittmar and Elisabeth Mohr and Johann Greil and Walter Mier and Lu{\'i}s Eduardo Becker and Peter A. Lang and Gerhard Opelz and Peter I Terness},
  journal={Clinical science},
  year={2015},
  volume={128 9},
  pages={
          593-607
        }
}
Our previous studies in rats showed that incubation of monocytic dendritic cells (DCs) with the chemotherapeutic drug mitomycin C (MMC) renders the cells immunosuppressive. Donor-derived MMC-DCs injected into the recipient prior to transplantation prolonged heart allograft survival. Although the generation of DCs is labour-intensive and time-consuming, peripheral blood mononuclear cells (PBMCs) can be easily harvested. In the present study, we analyse under which conditions DCs can be replaced… CONTINUE READING
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References

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Pretreatment of transfused donor splenocytes and allografts with mitomycin C attenuates acute rejection in heart transplantation in mice

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