Generation of strand breaks and formation of 8-hydroxy-2'-deoxyguanosine in DNA by a Thiol/Fe3+/O2-catalyzed oxidation system.

@article{Park1994GenerationOS,
  title={Generation of strand breaks and formation of 8-hydroxy-2'-deoxyguanosine in DNA by a Thiol/Fe3+/O2-catalyzed oxidation system.},
  author={J. Park and R. Floyd},
  journal={Archives of biochemistry and biophysics},
  year={1994},
  volume={312 1},
  pages={
          285-91
        }
}
  • J. Park, R. Floyd
  • Published 1994
  • Chemistry, Medicine
  • Archives of biochemistry and biophysics
Strand breaks are produced in pBluescript plasmid DNA by a metal-catalyzed oxidation system composed of Fe3+, O2, and a thiol as an electron donor. Formation of 8-hydroxy-2'-deoxyguanosine (8-OH-dG) in calf thymus DNA was also observed utilizing the same system. DNA damage was observed with the physiological thiols dihydrolipoic acid, glutathione, and cysteine as well as with the synthetic thiols dithiothreitol and 2-mercaptoethanol under a wide range of conditions. Both strand breaks and… Expand
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  • K. Hiramoto, K. Sekiguchi, +4 authors K. Kikugawa
  • Chemistry, Medicine
  • Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
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