Generation of stable mutants and targeted gene deletion strains in Cryptococcus neoformans through electroporation.

@article{Lin2015GenerationOS,
  title={Generation of stable mutants and targeted gene deletion strains in Cryptococcus neoformans through electroporation.},
  author={Xiaorong Lin and Nadia Chacko and Linqi Wang and Yashwant Pavuluri},
  journal={Medical mycology},
  year={2015},
  volume={53 3},
  pages={225-34}
}
Cryptococcus neoformans is the etiologic agent of cryptococcal meningitis that causes more than half a million deaths worldwide each year. This capsulated basidiomycetous yeast also serves as a model for micropathogenic studies. The ability to make stable mutants, either via ectopic integration or homologous recombination, has been accomplished using biolistic transformation. This technical advance has greatly facilitated the research on the basic biology and pathogenic mechanisms of this… CONTINUE READING
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