Generation of sp3111 transgenic RNAi mice via permanent integration of small hairpin RNAs in repopulating spermatogonial cells in vivoGeneration of sp3111 transgenic RNAi mice via permanent integration of small hairpin RNAs in repopulating spermatogonial cells in vivo.

@article{Shi2010GenerationOS,
  title={Generation of sp3111 transgenic RNAi mice via permanent integration of small hairpin RNAs in repopulating spermatogonial cells in vivoGeneration of sp3111 transgenic RNAi mice via permanent integration of small hairpin RNAs in repopulating spermatogonial cells in vivo.},
  author={Weili Shi and Tingyan Shi and Zheyu Chen and Jufang Lin and Xiaofeng Jia and Jian Wang and Huijuan Shi},
  journal={Acta biochimica et biophysica Sinica},
  year={2010},
  volume={42 2},
  pages={116-221}
}
The spermatid-specific gene, sp3111, is a new member of the four-transmembrane gene family. However, its reproductive biological function remains elusive. The aim of this study was to establish an sp3111-knockdown male mouse model for further studying the effect of suppression of sp3111 gene expression on its reproductive functions. Recombinant vectors of pSUPER-sp3111-shRNA, containing the transcribed functional small hairpin RNA sequence against different regions of mouse sp3111 mRNA, were… CONTINUE READING

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