Generation of self HLA-DR-specific CD3+CD4-CD8+ cytotoxic T cells in chronic graft-versus-host disease.

Abstract

To analyze the mechanism of chronic graft-versus-host disease (GVHD) characteristic of autoimmune disease, we used a cell-mediated lympholysis assay to study the autoreactivity of PBL from two patients after MHC-matched BMT. Our data indicate the induction of CD3+CD4-CD8+ autoreactive cytotoxic T lymphocytes (CTL) in the one patient with chronic GVHD and an… (More)

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@article{Yamamoto1994GenerationOS, title={Generation of self HLA-DR-specific CD3+CD4-CD8+ cytotoxic T cells in chronic graft-versus-host disease.}, author={M. Yamamoto and K. Sugihara and Fumio Ohtsuki and Yasuo Tsujino and A. Tanaka and T. Kamiya and Hisashi Wada and Akihisa Kanamaru and Hideaki Hara and Akiko Yano}, journal={Bone marrow transplantation}, year={1994}, volume={14 4}, pages={525-33} }