Generation of sRAGEhigh transgenic mice to study inflammaging.

@article{Peng2019GenerationOS,
  title={Generation of sRAGEhigh transgenic mice to study inflammaging.},
  author={Yunqian Peng and Han-Sol Park and Lisa Ann Tang and Naftali Horwitz and Li Lin},
  journal={Frontiers in bioscience},
  year={2019},
  volume={24},
  pages={
          555-563
        }
}
The receptor for advanced glycation end products (RAGE) interacts with multiple ligands and transmits inflammatory signals from damage- and pathogen-associated molecular patterns (DAMPs and PAMPs) to cellular programs. RAGE shares ligands with another group of PRRs, i.e., Toll-like receptors. Such ligand-receptor promiscuity generates coordinated and complex signaling patterns that provide a basis for the development of multiple inflammaging diseases. Soluble RAGE (sRAGE) functions as a RAGE… Expand
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