Generation of retinal pigment epithelial cells from small molecules and OCT4 reprogrammed human induced pluripotent stem cells.

@article{Krohne2012GenerationOR,
  title={Generation of retinal pigment epithelial cells from small molecules and OCT4 reprogrammed human induced pluripotent stem cells.},
  author={Tim U Krohne and Peter D. Westenskow and Toshihide Kurihara and David Fallon Friedlander and Mandy D. Lehmann and Alison L. Dorsey and Wenlin Wendy Li and Saiyong Zhu and Andrew J. Schultz and Junhua Wang and Gary Siuzdak and Sheng Ding and Martin Friedlander},
  journal={Stem cells translational medicine},
  year={2012},
  volume={1 2},
  pages={
          96-109
        }
}
Autologous retinal pigment epithelium (RPE) grafts derived from induced pluripotent stem cells (iPSCs) may be used to cure blinding diseases in which RPE dysfunction results in photoreceptor degeneration. Four-, two-, and one-factor-derived iPSCs (4F-, 2F-, and 1F-iPSCs, respectively) were differentiated into fully functional cuboidal pigmented cells in polarized monolayers that express RPE-specific markers. 1F-iPSCs-RPE (1F-iPS-RPE) strongly resembles primary human fetal RPE (hfRPE) based on… CONTINUE READING

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