Generation of reactive oxygen species during interaction of diesel exhaust particle components with NADPH-cytochrome P450 reductase and involvement of the bioactivation in the DNA damage.

@article{Kumagai1997GenerationOR,
  title={Generation of reactive oxygen species during interaction of diesel exhaust particle components with NADPH-cytochrome P450 reductase and involvement of the bioactivation in the DNA damage.},
  author={Yoshito Kumagai and Taichiro Arimoto and M Shinyashiki and Nobuhiro Shimojo and Yumi Nakai and Takahisa Yoshikawa and Masaru Sagai},
  journal={Free radical biology & medicine},
  year={1997},
  volume={22 3},
  pages={479-87}
}
Since the toxicity of diesel exhaust particles (DEP) after intratracheal injection, was suppressed by pretreatment with superoxide dismutase (SOD) modified with polyethylene glycol (Sagai et al. Free Rad. Biol. Med. 14: 37-47; 1993), the possibility that superoxide could be enzymatically and continuously generated from diesel exhaust particles (DEP), was examined. Nicotinamide-adenine dinucleotide phosphate, reduced (NADPH) oxidation was stimulated during interaction of a methanol extract of… CONTINUE READING
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