Corpus ID: 11142809

Generation of reactive oxygen radicals through bioactivation of mitomycin antibiotics.

@article{Pritsos1986GenerationOR,
  title={Generation of reactive oxygen radicals through bioactivation of mitomycin antibiotics.},
  author={C. Pritsos and A. Sartorelli},
  journal={Cancer research},
  year={1986},
  volume={46 7},
  pages={
          3528-32
        }
}
Mitomycin C (MC) is a naturally occurring anticancer agent which has been shown to be more cytotoxic to hypoxic tumor cells than to their aerobic counterparts. The mechanism of action of this agent is thought to involve biological reductive activation, to a species that alkylates DNA. A comparison of the cytotoxicity of MC to EMT6 tumor cells with that of the structural analogues porfiromycin (PM), N-(N',N'-dimethylaminomethylene)amine analogue of mitomycin C (BMY-25282), and N-(N',N… Expand
Cellular approaches to bioreductive drug mechanisms
DNA damage, cytotoxicity and free radical formation by mitomycin C in human cells.
Inhibition of mitomycin C's aerobic toxicity by the seleno-organic antioxidant PZ-51
Cellular pharmacology of quinone bioreductive alkylating agents
Formation of reactive oxygen species following bioactivation of gentamicin.
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