Generation of protective immunity against Orientia tsutsugamushi infection by immunization with a zinc oxide nanoparticle combined with ScaA antigen

@inproceedings{Ha2016GenerationOP,
  title={Generation of protective immunity against Orientia tsutsugamushi infection by immunization with a zinc oxide nanoparticle combined with ScaA antigen},
  author={Na Young Ha and Hyun Mu Shin and Prashant Sharma and Hyun Ah Cho and Chan-Ki Min and Hong-il Kim and Nguyễn Thị Hải Yến and Jae-Seung Kang and Ik-sang Kim and Myung-Sik Choi and Young Keun Kim and Nam-Hyuk Cho},
  booktitle={Journal of Nanobiotechnology},
  year={2016}
}
BackgroundZinc oxide nanoparticle (ZNP) has been applied in various biomedical fields. Here, we investigated the usage of ZNP as an antigen carrier for vaccine development by combining a high affinity peptide to ZNP.ResultsA novel zinc oxide-binding peptide (ZBP), FPYPGGDA, with high affinity to ZNP (Ka = 2.26 × 106 M−1) was isolated from a random peptide library and fused with a bacterial antigen, ScaA of Orientia tsutsugamushi, the causative agent of scrub typhus. The ZNP/ZBP-ScaA complex was… CONTINUE READING

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