Generation of pluripotent stem cells from adult human testis

  title={Generation of pluripotent stem cells from adult human testis},
  author={Sabine Conrad and Markus Renninger and Joerg Hennenlotter and Tina Wiesner and Lothar Just and Michael Bonin and Wilhelm K Aicher and H H B{\"u}hring and Ulrich Mattheus and Andreas Mack and H. Wagner and Stephen Minger and Matthias Matzkies and Michael Reppel and J{\"u}rgen Hescheler and Karl-Dietrich Sievert and Arnulf Stenzl and Thomas Skutella},
Human primordial germ cells and mouse neonatal and adult germline stem cells are pluripotent and show similar properties to embryonic stem cells. Here we report the successful establishment of human adult germline stem cells derived from spermatogonial cells of adult human testis. Cellular and molecular characterization of these cells revealed many similarities to human embryonic stem cells, and the germline stem cells produced teratomas after transplantation into immunodeficient mice. The… CONTINUE READING
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