Generation of plasma cells from peripheral blood memory B cells: synergistic effect of interleukin-10 and CD27/CD70 interaction.

@article{Agematsu1998GenerationOP,
  title={Generation of plasma cells from peripheral blood memory B cells: synergistic effect of interleukin-10 and CD27/CD70 interaction.},
  author={Kazunaga Agematsu and Haruo Nagumo and Yoshiharu Oguchi and Tsutomu Nakazawa and Kazuyo Fukushima and Kozo Yasui and Shigeki Ito and Tetsuji Kobata and Chikao Morimoto and Atsushi Komiyama},
  journal={Blood},
  year={1998},
  volume={91 1},
  pages={173-80}
}
B cells can differentiate into the antibody-secreting cells, plasma cells, whereas the crucial signals that positively control the entry into the pathway to plasma cells have been unclear. Triggering via CD27 by CD27 ligand (CD70) on purified peripheral blood B cells yielded an increase in the number of plasma cells in the presence of interleukin-10 (IL-10… CONTINUE READING