Generation of phosphorylcholine as an essential event in the activation of Raf-1 and MAP-kinases in growth factors-induced mitogenic stimulation.

@article{Jimnez1995GenerationOP,
  title={Generation of phosphorylcholine as an essential event in the activation of Raf-1 and MAP-kinases in growth factors-induced mitogenic stimulation.},
  author={Benilde Jim{\'e}nez and Luis Del Peso and Silvia Montaner and Pilar Albors Esteve and Juan Carlos Lacal},
  journal={Journal of cellular biochemistry},
  year={1995},
  volume={57 1},
  pages={141-9}
}
Cell proliferation is regulated by an appropriate combination of intracellular signals involving activation of kinases and the generation of phospholipid metabolites. We report here that growth factors induce a biphasic generation of phosphorylcholine (PCho) in quiescent NIH 3T3 cells, resulting in an early and transient increase at 100 s and a larger and sustained increase after 3 h of stimulation. Generation of PCho at both early and late times of growth factors stimulation results from the… CONTINUE READING